Technical Expertise
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Selected publications grouped by technical area…
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Surface Characterization
A. M. L. Sousa, T.-D. Li, S. Varghese, P. J. Halling, K. H. A. Lau, “Plant-Based Polyphenol Coatings for Enabling Active Protein Surfaces”, ACS Appl. Mater. Interfaces, 10, 39353–39362 (2018). DOI: 10.1021/acsami.8b13793
M.P. Conte, K.H.A. Lau, R.V. Ulijn, "Biocatalytic self-assembly using reversible and irreversible enzyme immobilization", ACS Appl. Mater. Interfaces, 9, 3266 (2017). DOI: 10.1021/acsami.6b13162
J. Y. Ryu, I. T. Song, K. H. A. Lau, P. B. Messersmith, T.-Y. Yoon, H. Lee, “New antifouling platform characterized by single-molecule imaging”. ACS Appl. Mater. Interf., 6, 3553, (2014). DOI: 10.1021/am4057387
K. H. A. Lau, C. Ren, S. H. Park, I. Szleifer, P. B. Messersmith, "An Experimental-Theoretical Analysis of Protein Adsorption on Peptidomimetic Polymer Brushes". Langmuir, 28, 2288-2298 (2012). PMID: 22107438; PMCID: PMC3269508.
SPR - Surface Plasmon Resonance Spectroscopy
K.H.A. Lau, J. Bang, C.J. Hawker, D.H. Kim, W. Knoll, "Modulation of Protein-Surface Interactions on Nanopatterned Polymer Films", Biomacromolecules, 10, 1061-1066 (2009).
K.H.A. Lau, J. Bang, D.H. Kim, W. Knoll, "Self-assembly of Protein Nanoarrays on Block Copolymer Templates", Adv. Funct. Mater., 18, 3148-3157 (2008).
M. Ito, F. Nakamura, A. Baba, K. Tamada, H. Ushijima, K.H.A. Lau, A. Manna, W. Knoll, "Enhancement of surface plasmon resonance signals by gold nanoparticles on high-density DNA microarrays", J. Phys. Chem. C, 111, 11653-11662 (2007).
K.H.A. Lau, C. Huang, N. Yakovlev, Z.K. Chen, S.J. O'Shea, "Direct adsorption and monolayer self-assembly of acetyl-protected dithiols", Langmuir, 22, 2968-2971 (2006).
XPS, TOF-SIMS
A. M. L. Sousa, T.-D. Li, S. Varghese, P. J. Halling, K. H. A. Lau, “Plant-Based Polyphenol Coatings for Enabling Active Protein Surfaces”, ACS Appl. Mater. Interfaces, 10, 39353–39362 (2018). DOI: 10.1021/acsami.8b13793
K.H.A. Lau, C. Huang, N. Yakovlev, Z.K. Chen, S.J. O'Shea, "Direct adsorption and monolayer self-assembly of acetyl-protected dithiols", Langmuir, 22, 2968-2971 (2006).
Y.F. Xing, S.F.Y. Li, A.K.H. Lau, S.J. O'Shea, "Electrochemical impedance spectroscopy study of mixed thiol monolayers on gold", J. Electroanal. Chem., 583, 124-132 (2005).
OWS - Optical Waveguide Spectroscopy
T.D. Lazzara, K.H.A. Lau, A.I. Abou-Kandil, A.M. Caminade, P. Majoral, W. Knoll, "Polyelectrolyte Layer-by-Layer Deposition in Cylindrical Nanopores", ACS Nano, 4, 3909-3920 (2010).
T.D. Lazzara, K.H.A. Lau, W. Knoll, "Mounted Nanoporous Anodic Alumina Thin Films as Planar Optical Waveguides", J. Nanosci. Nanotech., 10, 4293-4299 (2010).
K. H. A. Lau, P. J. Cameron, H. Duran, A. I. Abou-Kandil, W. Knoll, "Nanoporous Waveguides as Versatile, High-Sensitivity Biosensors", in Surface Design: Applications in Bioscience and Nanotechnology (Eds.: R. Foerch, H. Schoenherr, A. T. A. Jenkins), Wiley-VCH, Weinheim, pp. 383-401 (2009).
K.H.A. Lau, L.S. Tan, K. Tamada, M.S. Sander, W. Knoll, "Highly sensitive detection of processes occurring inside nanoporous anodic alumina templates: A waveguide optical study", J. Phys. Chem. B, 108, 10812-10818 (2004).
Controlling Protein- and Cell-Surface Interactions
K. H. A. Lau, T. S. Sileika, S. H. Park, A. M. L. Sousa, P. Burch, I. Szleifer, P. B. Messersmith, “Molecular Design of Antifouling Polymer Brushes using Sequence-Specific Peptoids”, accepted for publication in Adv. Mater. Interf. (2014).
Q. Li, K.H.A. Lau, E.K. Sinner, D.H. Kim, W. Knoll, "The Effect of Fluid Flow on Selective Protein Adsorption on Polystyrene-block-Poly(methyl methacrylate) Copolymers", Langmuir, 25, 12144-12150 (2009).
K.H.A. Lau, J. Bang, C.J. Hawker, D.H. Kim, W. Knoll, "Modulation of Protein-Surface Interactions on Nanopatterned Polymer Films", Biomacromolecules, 10, 1061-1066 (2009).
R.Y.H. Lim, N.P. Huang, J. Koser, J. Deng, K.H.A. Lau, K. Schwarz-Herion, B. Fahrenkrog, U. Aebi, "Flexible phenylalanine-glycine nucleoporins as entropic barriers to nucleocytoplasmic transport", Proc. Natl. Ac. Sci. USA, 103, 9512-9517 (2006).
Surface Modification
K. H. A. Lau, T. S. Sileika, S. H. Park, A. M. L. Sousa, P. Burch, I. Szleifer, P. B. Messersmith, “Molecular Design of Antifouling Polymer Brushes using Sequence-Specific Peptoids”, accepted for publication in Adv. Mater. Interf. (2014).
T. S. Sileika, D. G. Barrett, R. Zhang, K. H. A. Lau, P. B. Messersmith, “Colorless Multifunctional Coatings Inspired by Polyphenols Found in Tea, Chocolate and Wine”, Angew. Chem. Int. Ed., 52, 10766-10770 (2013).
H. O. Ham, Z. Q. Liu, K. H. A. Lau, H. Lee, P. B. Messersmith, "Facile DNA Immobilization on Surfaces through a Catecholamine Polymer". Angew. Chem. Int. Ed., 50, 732-736 (2011).
K.H.A. Lau, C. Huang, N. Yakovlev, Z.K. Chen, S.J. O'Shea, "Direct adsorption and monolayer self-assembly of acetyl-protected dithiols", Langmuir, 22, 2968-2971 (2006).
Nanopores/Nanoporous Materials
A. M. L. Sousa, T.-D. Li, S. Varghese, P. J. Halling, K. H. A. Lau, “Plant-Based Polyphenol Coatings for Enabling Active Protein Surfaces”, ACS Appl. Mater. Interfaces, 10, 39353–39362 (2018). DOI: 10.1021/acsami.8b13793
Lazzara, T.D., K.H.A. Lau, W. Knoll, A. Janshoff, and C. Steinem, “Macromolecular shape and interactions in layer-by-layer assemblies within cylindrical nanopores”. Beilstein J. Nanotech., 3, 475-484 (2012).
O. Azzaroni, K. H. A. Lau, Review: "Layer-by-layer Assemblies in Nanoporous Templates: Nano-Organized Design and Applications of Soft Nanotechnology". Soft Matter, 7, 8709-8724 (2011). PMID: 22216060; PMCID: PMC3247160.
T.D. Lazzara, K.H.A. Lau, A.I. Abou-Kandil, A.M. Caminade, P. Majoral, W. Knoll, "Polyelectrolyte Layer-by-Layer Deposition in Cylindrical Nanopores", ACS Nano, 4, 3909-3920 (2010).
D.H. Kim, K.H.A. Lau, W. Joo, J. Peng, U. Jeong, C.J. Hawker, J.K. Kim, T.P. Russell, W. Knoll, "An optical waveguide study on the nanopore formation in block copolymer/homopolymer thin films by selective solvent swelling", J. Phys. Chem. B, 110, 15381-15388 (2006).
Polyphenol Coatings
A. M. L. Sousa, T.-D. Li, S. Varghese, P. J. Halling, K. H. A. Lau, “Plant-Based Polyphenol Coatings for Enabling Active Protein Surfaces”, ACS Appl. Mater. Interfaces, 10, 39353–39362 (2018). DOI: 10.1021/acsami.8b13793
M.P. Conte, K.H.A. Lau, R.V. Ulijn, "Biocatalytic self-assembly using reversible and irreversible enzyme immobilization", ACS Appl. Mater. Interfaces, 9, 3266 (2017). DOI: 10.1021/acsami.6b13162
T. S. Sileika, D. G. Barrett, R. Zhang, K. H. A. Lau, P. B. Messersmith, “Colorless Multifunctional Coatings Inspired by Polyphenols Found in Tea, Chocolate and Wine”, Angew. Chem. Int. Ed., 52, 10766-10770 (2013).
Antifouling Polymer Brushes
K. H. A. Lau, T. S. Sileika, S. H. Park, A. M. L. Sousa, P. Burch, I. Szleifer, P. B. Messersmith, “Molecular Design of Antifouling Polymer Brushes using Sequence-Specific Peptoids”, accepted for publication in Adv. Mater. Interf. (2014).
J. Y. Ryu, I. T. Song, K. H. A. Lau, P. B. Messersmith, T.-Y. Yoon, H. Lee, “New antifouling platform characterized by single-molecule imaging”. ACS Appl. Mater. Interf., 6, 3553, (2014). DOI: 10.1021/am4057387.
K. H. A. Lau, C. Ren, T. S. Sileika, S. H. Park, I. Szleifer, P. B. Messersmith, "Surface Grafted Polysarcosine as a Peptoid Antifouling Polymer Brush". Langmuir, 28, 16099-16107 (2012). PMID: 23101930; PMCID PMC3530414.
K. H. A. Lau, C. Ren, S. H. Park, I. Szleifer, P. B. Messersmith, "An Experimental-Theoretical Analysis of Protein Adsorption on Peptidomimetic Polymer Brushes". Langmuir, 28, 2288-2298 (2012). PMID: 22107438; PMCID: PMC3269508.